UC-II Non-Denatured Type II Collagen
Supports joint health and encourages a comfortable daily life.
**Definition and Characteristics of UC-II** Undenatured type II collagen (UC-II) is a functional material that has been processed while retaining the original triple helix structure of type II collagen, which is abundant in articular cartilage. Unlike typical collagen peptides, which have their structure broken down by heating or hydrolysis, UC-II fundamentally differs by maintaining its three-dimensional structure through low-temperature processing. **Unique Mechanism of Action: "Oral Immune Tolerance"** UC-II acts not merely as a nutritional supplement that is digested and absorbed, but through an immunological mechanism known as "Oral Tolerance." Process: The orally ingested UC-II reaches the Peyer's patches in the gut-associated lymphoid tissue (GALT) of the small intestine while maintaining its undenatured state. Effect: There, it is recognized by antigen-presenting cells, which induces regulatory T cells (Treg) to secrete anti-inflammatory cytokines (such as IL-10 and TGF-β), contributing to the suppression of joint inflammation and the maintenance of cartilage homeostasis. **Decisive Difference from Other Products: "Origin" and "Pinnacle"** UC-II is a pioneering material that was the first in the world to be commercialized as a supplement ingredient for joint health.
- Company：Lonza K.K.
- Price：Other
